Testicular Function in Klinefelter Syndrome
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چکیده
منابع مشابه
Testicular Function in Klinefelter Syndrome
Klinefelter syndrome (KS) is the most common genetic form of male hypogonadism, but the phenotype becomes evident only after puberty. During childhood, and even during early puberty, pituitary-gonadal function in 47,XXY subjects is relatively normal, but from midpuberty onwards, FSH and LH levels increase to hypergonadotropic levels, inhibin B decreases to undetectable levels, and testosterone ...
متن کاملTesticular function and fertility in men with Klinefelter syndrome: a review.
Klinefelter syndrome, 47,XXY (KS), is the most frequent sex chromosome aberration in males, affecting 1 in 660 newborn boys. The syndrome is characterized by testicular destruction with extensive fibrosis and hyalinization of the seminiferous tubules resulting in small testes, hypergonadotropic hypogonadism, and azoospermia in the majority of cases. Until recently, infertility was considered an...
متن کاملTesticular function in Klinefelter's syndrome.
Testicular venous effluent was obtained by selective catheterization from 2 subjects with chromatin-positive Klinefelter's syndrome. In both of these subjects the testosterone concentration was reduced, whereas the estradiol concentration was normal or slightly increased in 1 and reduced to a much lesser extent than the testosterone level in the other. The testosterone/estradiol ratios in both ...
متن کاملKlinefelter syndrome
Some males with Klinefelter syndrome have the extra X chromosome only in some of their cells (mosaic Klinefelter syndrome). In addition, 46,XX males also exist and it is caused by translocation of Y material including sex determining region (SRY) to the X chromosome during paternal meiosis. Formal cytogenetic analysis is necessary to make a definite diagnosis, and more obvious differences in ph...
متن کاملKlinefelter syndrome
Some males with Klinefelter syndrome have the extra X chromosome only in some of their cells (mosaic Klinefelter syndrome). In addition, 46,XX males also exist and it is caused by translocation of Y material including sex determining region (SRY) to the X chromosome during paternal meiosis. Formal cytogenetic analysis is necessary to make a definite diagnosis, and more obvious differences in ph...
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ژورنال
عنوان ژورنال: Hormone Research in Paediatrics
سال: 2008
ISSN: 1663-2818,1663-2826
DOI: 10.1159/000117387